Predicting Flu Vaccine Efficacy in the Elderly

ID-10062525A study by researchers Emory University and the University of California sought to find out what factors inhibit strong responses to seasonal flu vaccines in the elderly and why anti-flu antibodies last longer after vaccination in some people through a systems biology approach.

The team worked with 400 volunteers who had received the seasonal flu vaccine. Their blood samples were analyzed for strong immune responses brought about by gene expression and the subjects tracked for five consecutive seasons.

Shankar Subramaniam, Ph.D, co-senior author, states that their findings will guide the development of new vaccines that will offer both better protection and long-lasting immunity to at-risk populations.

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